Detection of fluorine labeled Herceptin using cellular 19F MRI ex vivo
نویسندگان
چکیده
منابع مشابه
In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence
Mesenchymal stem cells (MSC) are used to restore deteriorated cell environments. There is a need to specifically track these cells following transplantation in order to evaluate different methods of implantation, to follow their migration within the body, and to quantify their accumulation at the target. Cellular magnetic resonance imaging (MRI) using fluorine-based nanoemulsions is a great mea...
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BACKGROUND Emulsified perfluorocarbons (PFCs) are preferentially phagocytized by monocytes/macrophages and are readily detected by (19)F MRI. This study tests the hypothesis that (19)F MRI can be used to quantitate pulmonary inflammation by tracking of infiltrating PFC-loaded monocytes. METHODS AND RESULTS Pneumonia was induced in mice by intratracheal instillation of lipopolysaccharides (LPS...
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BACKGROUND 19F-MRI and 19F-MRS can identify specific cell types after in-vitro or in-vivo 19F-labeling. Knowledge on the potential to track in-vitro 19F-labeled immune cells in tumor models by 19F-MRI/MRS is scarce. AIM To study 19F-based MR techniques for in-vivo tracking of adoptively transferred immune cells after in-vitro 19F-labeling, i.e. to detect and monitor their migration non-invasi...
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BACKGROUND In this study we used cellular magnetic resonance imaging (MRI) to detect mesenchymal stem cells (MSC) labeled with a Fluorine-19 (19F) agent. 19F-MRI offers unambiguous detection and in vivo quantification of labeled cells. METHODS We investigated two common stem cell transplant mouse models: an immune competent, syngeneic transplant model and an immune compromised, xenograft tran...
متن کاملCustomizable PLGA-encapsulated perfluorocarbon particles for in vivo 19F MRI
Introduction Magnetic Resonance Imaging (MRI) using H spins from water is a major in vivo imaging modality. With F MRI, cells labeled with fluorinated compounds can be visualized in the body without interference of the large H background from mobile water in tissues. Importantly, it also allows quantification of the number of cells directly from the image data [1, 2]. However, the perfluorocarb...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical and Biomedical Analysis
سال: 2010
ISSN: 0731-7085
DOI: 10.1016/j.jpba.2009.10.008